BenU faculty since 2009
Postdoctoral Associate: University of California-Irvine (2008-2009)
Ph.D.: The Pennsylvania State University (2008)
B.A.: Augustana College (2001)


Courses Taught
General Chemistry I and II, Inorganic Chemistry, Inorganic Synthesis Laboratory, Bioinorganic Chemistry, Principles of Biochemistry, Analytical Chemistry Laboratory I, Materials Science

Award and Recognition:
College of Science Dean's Award for Teaching Excellence, 2016
College of Science Dean's Award for Research, 2013
Cottrell College Science Award, 2011

Research Area:
Bioinorganic Chemistry, Redox-Active Ligands, Hemoproteins, Catalysis

Current Research Projects:

  • Protein project: Utilizing the potential of metal-replaced hemoproteins in order to promote new types of reactivity and catalysis. The design of metalloenzymes in order to produce new types of biocatalysts has received ongoing attention in the industrial community. The major aim of this project is to utilize hemoproteins as protein scaffolds to introduce new active sites that are produced by synthetic methods in order to improve functionality. Many of these types of proteins have robust protein structures and their heme cofactors can easily be replaced. This proposal has two main themes: (1) replacement of metal ions in the porphyrins of hemoproteins and (2) the incorporation of porphyrin derivatives into the protein matrix with the goal of promoting new reactivity and catalysis in order to make new oxygen-containing molecules.
  • Synthesis project: Exploring metal complexes with redox-active ligands to promote new types of reactivity and catalysis. Transition metal complexes that perform small molecule transformations utilize multi-electron processes. Two-electron oxidations include C-H bond oxidation and reduction of protons to dihydrogen, while oxidation of water is a four electron process and reduction of dinitrogen is a six electron process. To perform multi-electron transformations many times one or more transition metals are implicated invoking a change in oxidation states of the metal or metals. Redox-active ligands containing oxygen, nitrogen, and sulfur have gained considerable attention recently as ligands for transition metals to become involved in electron donation that is typically assigned to metal redox processes. This research project seeks to employ an alternative to a many-electron process involving transition metals by including redox active ligands coordinated to the metal center to supply the necessary oxidative or reducing equivalents to perform desirable chemical transformations.


Current Research Collaborators:

  • Andrew S. Borovik, University of California-Irvine
  • Michael T. Green, University of California-Irvine


Research Grants and Funding:

  1. Synthesis of Transition Metal Complexes with Redox-active Ligands for Catalysis. Research Corporation Cottrell College Science Awards, $35,000 + $20,289.12 matching funds, July 1, 2011 – June 30, 2013.
    Note:  Allowed the chemistry department to obtain an inert atmospheres glovebox equipped with a solvent purification system.
  2. Multi-University Integration of Solid-State Chemistry and Powder X-ray Diffraction into the Undergraduate Curriculum. Co- Principle Investigator.  National Science Foundation-TUES, $115,272, August 15 2012 - July 31 2014.


Professional Activities:

  • 2017-present , VIPEr (Virtual Inorganic Pedagogical Electronic Resource) administration team
  • 2017-present, Membership, American Association for the Advancement of Science
  • 2017, Reviewer, reviewed grant proposals for the American Chemical Society Petroleum Research Fund
  • 2017-present, Panelist, reviewed grant proposals and served on a 2-day panel for the National Science Foundation for the Improving Undergraduate STEM Education Program
  • 2017-present, Chair, Women Chemists Committee, American Chemical Society Chicago Section, nominated for a ChemLuminary award
  • 2017, Organizer, “Exploring IONiC VIPEr: A Pedagogical Resource and Online Community,” workshop for the division of Chemistry of ACCA
  • 2016-2018, Director, Chicago Section American Chemical Society Board
  • 2016, Organizer, “Fostering Success in General Chemistry” workshop for the division of Chemistry of ACCA
  • 2016, Organizer, “Fostering Success in General Chemistry” symposium at the 2016 Biennial Conference on Chemical Education
  • 2016, Contributor, “General Chemistry Performance Expectations” at the American Chemical Society headquarters in Washington, D. C.
  • 2015-present, Reviewer, American Chemical Society journals
  • 2014-present, Reviewer, MDPI journals
  • 2012-present, Reviewer, American Chemical Society Student Chapters
  • 2004-present, Membership, American Chemical Society, Inorganic and Bioinorganic Divisions and Chemical Education Division


Current and Former Research Students:

  • Habib Hassan, 2021, Biology major
  • Grace Wangler, 2020, Chemistry major
  • Janina Nguyen, 2020, Chemistry major
  • Ismail Ahmad, 2019, Physics major
  • Ibrahim Alwan, 2019, Health Science major
  • James Hoshell, Jr., 2018, Chemistry major
  • Ferhan Syed, 2018, Chemistry major
  • Jonathan Mason, 2017, Biochemisty and Molecular Biology major
  • Rachel Majerczk, 2017, Biochemistry and Molecular Biology major
  • Sana Quadri, 2016, Chemistry major
  • Jonathan Bell, 2016, Biochemistry and Molecular Biology major
  • Maham Ahmed, 2016, Health Science major
  • Margaret Julien, 2016, Biochemistry and Molecular Biology major
  • Jonathan Mason, 2017, Biochemisty and Molecular Biology major
  • Rachel Majerczk, 2017, Biochemistry and Molecular Biology major
  • Rabia Choudhry, 2015, Biochemistry and Molecular Biology major
  • Eryn Pondo, 2015, Chemistry major
  • Antoinette White, 2016, Biochemistry and Molecular Biology major
  • Payal Shukla, 2016, Biology major
  • Farah Khan, 2015, Biology major
  • Seerat Hassan, 2015, Biochemistry and Molecular Biology major
  • Malak Hamdan, 2015, Biology major
  • Phaguni Nangia, 2015, Biology major
  • Humdoon Choudhry, 2015, Biochemistry and Molecular Biology major
  • Zakaria Malik, 2016, Biology major
  • Daniel Cygal, 2014, Biochemistry and Molecular Biology major
  • Bosky Parikh, 2014, Chemistry major
  • Eman Sahloul, Biochemistry and Molecular Biology major
  • Kevin Khoury, 2013, Health Science
  • Sandra Tovalin-Schmidt, 2013, Chemistry
  • Ashraf Uddin, 2013, Health Science
  • Joey Hua, 2013, Biochemistry and Molecular Biology
  • Tahreem Iqbal, 2012, Biochemistry and Molecular Biology
  • David Kamber, 2011, Biochemistry and Molecular Biology
  • Ankit Parikh, 2011, Biochemistry and Molecular Biology
  • Daniel Furnari, 2010, Chemistry
  • Robert Khoury, 2010, Health Science
  • Sharvil Boda, 2010, Health Science

Recent Publications
Pennsylvania State University

  • “X-ray Absorption Spectroscopy of Chloroperoxidase Compound I: New Insight into the Reactive Intermediate of P450 Chemistry.” Kari L. Stone, Rachel K. Behan, and Michael T. Green.* Proceedings of the National Academy of Sciences, USA, 2005, 102, 16563-16565.
  • “Evidence for Two Ferryl Species in Chloroperoxidase Compound II.” Kari L. Stone, Lee M. Hoffart, Rachel K. Behan, Carsten Krebs, and Michael T. Green.* Journal of the American Chemical Society, 2006, 128, 6147-6153.
  • “Resonance Raman Spectroscopy of Chloroperoxidase Compound II Provides Direct Evidence for the Existence of an Iron(IV)-Hydroxide Species.”  Kari L. Stone, Rachel K. Behan, and Michael T. Green.* Proceedings of the National Academy of Sciences, USA, 2006, 103, 12307-12310.
  • “Evidence for Basic Ferryls in Cytochromes P450.” Rachel K. Behan, Lee M. Hoffart, Kari L. Stone, Carsten Krebs, and Michael T. Green.* Journal of the American Chemical Society, 2006, 128, 11471-11474.
  • “Reaction of Cytochrome P450BM-3 and Peroxynitrite Yields Nitrosyl Complex.” Rachel K. Behan, Lee M. Hoffart, Kari L. Stone, Carsten Krebs, and Michael T. Green.*  Journal of the American Chemical Society, 2007, 129, 5855-5859.

University of California-Irvine

  • “Lessons from Nature: Unraveling Biological C-H Bond Activation.” Kari L. Stone and A. S. Borovik.*  Current Opinion in Chemical Biology, 2009, 13, 1-5.

Benedictine University

  • “Improving the Success of First Term General Chemistry Students at a Liberal Arts Institution.” Kari L. Stone, Sarah E. Shaner, and Carol M. Fendrick. Education Sciences, 2018, 8, 5.
  • “Advances in Engineered Hemoproteins that Promote Biocatalysis.” Kari L. Stone and Syeda M. Ahmed. Inorganics 2016, 4(2), 12.
  • "Manganese-Substituted Myoglobin: Characterization and Reactivity of an Oxidizing Intermediate towards a Weak C-H Bond.” Kari L. Stone*, Joey Hua, and Humdoon Choudhry.  Inorganics 2015, 3, 219-229.
  • “Preparation and Properties of an MnIV-Hydroxide Complex: Proton and Electron Transfer at a Mononuclear Manganese Site and its Relationship to the Oxygen Evolving Complex within Photosystem II.” Taketo Taguchi, Kari L. Stone, Rupal Gupta, Benedikt Kaiser-LaSalle, Junko Yano, Michael P. Hendrich, and A. S. Borovik.* Chemical Science, 2014, 5, 3064-3071
  • “Formation, Structure, and EPR Detection of a High Spin FeIV-Oxo Species Derived from Either an FeIII-Oxo or FeIII-OH Complex.”  David C. Lacy, Rupal Gupta, Kari L. Stone, John Greaves, Joseph W. Ziller, Michael P. Hendrich,* and A. S. Borovik.* Journal of the American Chemical Society, 2010, 132, 12188-12190 (Communication).


Peer-Reviewed and Invited Presentations:
Oral Presentations:

  • “Synthesis of 1st Row Transition Metal Complexes with Redox-active Ligands.” Science and Sociability Seminar, Benedictine University; February 5, 2010.
  • "Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” Chicago ACS September 2012 Meeting, Benedictine University; September 20, 2012.
  • “Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” 245th American Chemical Society Meeting. New Orleans, LA; April 2013.
  • “Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” Faculty Colloquium, Benedictine University; April 19, 2013.

Poster Presentations:

  • “Preparation of Synthetic Conjugated Myoglobin to Promote New Reactivity.” 253rd American Chemical Society National Meeting. San Francisco, CA, 2017.
  • “Preparation of Substituted Myoglobin to Promote New Reactivities.” 250th American Chemical Society Meeting. Boston, MA, 2015.
  • “Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” 246th American Chemical Society Meeting. Indianapolis, IN, 2013.
  • “Synthesis of Transition Metal Complexes with Redox-active Ligands for Catalysis” Kari L. Stone. 243rd American Chemical Society. San Diego, CA, 2012.

Kari Stone, Ph.D.

Birck 330 | 630-829-6559
kstone@ben.edu

 


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William R. Law, Ph.D
Dean of the College of Science

Tonia Rucker, Assistant to the Dean
Email: trucker@ben.edu
Phone: (630) 829-6187
Fax: (630) 829-6186

Hours: 8:30 a.m. - 4:00 p.m.

By Mail:
Benedictine University
5700 College Road
Birck Hall Room 119
Lisle, IL 60532