BenU faculty since 2009
Postdoctoral Associate: University of California-Irvine (2008-2009)
Ph.D.: The Pennsylvania State University (2008)
B.A.: Augustana College (2001)
General Chemistry I and II, Inorganic Chemistry, Inorganic Synthesis Laboratory, Bioinorganic Chemistry, Principles of Biochemistry, Analytical Chemistry Laboratory I, Materials Science
Award and Recognition:
College of Science Dean's Award for Research, 2013
Cottrell College Science Award, 2011
Bioinorganic Chemistry, Redox-Active Ligands, Nitrogen Group Transfer, Catalysis
Current Research Projects:
Current Research Collaborators:
- Protein project: Utilizing the potential of metal-replaced hemoproteins in order to promote new types of reactivity and catalysis. The design of metalloenzymes in order to produce new types of biocatalysts has received ongoing attention in the industrial community. The major aim of this project is to utilize hemoproteins as protein scaffolds to introduce new active sites that are produced by synthetic methods in order to improve functionality. Many of these types of proteins have robust protein structures and their heme cofactors can easily be replaced. This proposal has two main themes: (1) replacement of metal ions in the porphyrins of hemoproteins and (2) the incorporation of porphyrin derivatives into the protein matrix with the goal of promoting new reactivity and catalysis in order to make new oxygen-containing molecules.
- Synthesis project: Exploring metal complexes with redox-active ligands to promote new types of reactivity and catalysis. Transition metal complexes that perform small molecule transformations utilize multi-electron processes. Two-electron oxidations include C-H bond oxidation and reduction of protons to dihydrogen, while oxidation of water is a four electron process and reduction of dinitrogen is a six electron process. To perform multi-electron transformations many times one or more transition metals are implicated invoking a change in oxidation states of the metal or metals. Redox-active ligands containing oxygen, nitrogen, and sulfur have gained considerable attention recently as ligands for transition metals to become involved in electron donation that is typically assigned to metal redox processes. This research project seeks to employ an alternative to a many-electron process involving transition metals by including redox active ligands coordinated to the metal center to supply the necessary oxidative or reducing equivalents to perform desirable chemical transformations.
- Andrew S. Borovik, University of California-Irvine
- Michael T. Green, University of California-Irvine
Research Grants and Funding:
- Synthesis of Transition Metal Complexes with Redox-active Ligands for Catalysis. Research Corporation Cottrell College Science Awards, $35,000 + $20,289.12 matching funds, July 1, 2011 – June 30, 2013.
Note: Allowed the chemistry department to obtain an inert atmospheres glovebox equipped with a solvent purification system.
- Multi-University Integration of Solid-State Chemistry and Powder X-ray Diffraction into the Undergraduate Curriculum. Co- Principle Investigator. National Science Foundation-TUES, $115,272, August 15 2012 - July 31 2014.
- Reviewer, JACS
- Reviewer, American Chemical Society student chapters
- Director, Chicago Section ACS
- Learning community development for a green and environmental chemistry-focused laboratory
- Member, International Center for Academic Integrity
- Member, American Chemical Society, Inorganic and Bioinorganic Division
- Member, Iota Sigma Pi, National Honor Society for Women in Chemistry
- Member, International Union of Pure and Applied Chemistry
- Lead Guest Editor, Special Issue on "Metal-Oxygen Species in Oxidative Processes from Enzymatic and Biomimetic Perspectives” in Bioinorganic Chemistry and Applications
- Secretary, Chemistry Division, ACCA Chemistry Division, 2010-2011
- Chair, Chemistry Division, ACCA Chemistry Division, 2011-2012
Current and Former Research Students:
- Jonathan Bell, 2016, Biochemistry and Molecular Biology major
- Maham Ahmed, 2016, Health Science major
- Margaret Julien, 2016, Biochemistry and Molecular Biology major
- Jonathan Mason, 2017, Biochemisty and Molecular Biology major
- Rachel Majerczk, 2017, Biochemistry and Molecular Biology major
- Rabia Choudhry, 2015, Biochemistry and Molecular Biology major
- Eryn Pondo, 2015, Chemistry major
- Antoinette White, 2016, Biochemistry and Molecular Biology major
- Payal Shukla, 2016, Biology major
- Farah Khan, 2015, Biology major
- Seerat Hassan, 2015, Biochemistry and Molecular Biology major
- Malak Hamdan, 2015, Biology major
- Phaguni Nangia, 2015, Biology major
- Humdoon Choudhry, 2015, Biochemistry and Molecular Biology major
- Zakaria Malik, 2016, Biology major
- Daniel Cygal, 2014, Biochemistry and Molecular Biology major
- Bosky Parikh, 2014, Chemistry major
- Eman Sahloul, Biochemistry and Molecular Biology major
- Kevin Khoury, 2013, Health Science
- Sandra Tovalin-Schmidt, 2013, Chemistry
- Ashraf Uddin, 2013, Health Science
- Joey Hua, 2013, Biochemistry and Molecular Biology
- Tahreem Iqbal, 2012, Biochemistry and Molecular Biology
- David Kamber, 2011, Biochemistry and Molecular Biology
- Ankit Parikh, 2011, Biochemistry and Molecular Biology
- Daniel Furnari, 2010, Chemistry
- Robert Khoury, 2010, Health Science
- Sharvil Boda, 2010, Health Science
Pennsylvania State University
- “X-ray Absorption Spectroscopy of Chloroperoxidase Compound I: New Insight into the Reactive Intermediate of P450 Chemistry.” Kari L. Stone, Rachel K. Behan, and Michael T. Green.* Proceedings of the National Academy of Sciences, USA, 2005, 102, 16563-16565.
- “Evidence for Two Ferryl Species in Chloroperoxidase Compound II.” Kari L. Stone, Lee M. Hoffart, Rachel K. Behan, Carsten Krebs, and Michael T. Green.* Journal of the American Chemical Society, 2006, 128, 6147-6153.
- “Resonance Raman Spectroscopy of Chloroperoxidase Compound II Provides Direct Evidence for the Existence of an Iron(IV)-Hydroxide Species.” Kari L. Stone, Rachel K. Behan, and Michael T. Green.* Proceedings of the National Academy of Sciences, USA, 2006, 103, 12307-12310.
- “Evidence for Basic Ferryls in Cytochromes P450.” Rachel K. Behan, Lee M. Hoffart, Kari L. Stone, Carsten Krebs, and Michael T. Green.* Journal of the American Chemical Society, 2006, 128, 11471-11474.
- “Reaction of Cytochrome P450BM-3 and Peroxynitrite Yields Nitrosyl Complex.” Rachel K. Behan, Lee M. Hoffart, Kari L. Stone, Carsten Krebs, and Michael T. Green.* Journal of the American Chemical Society, 2007, 129, 5855-5859.
University of California-Irvine
- “Lessons from Nature: Unraveling Biological C-H Bond Activation.” Kari L. Stone and A. S. Borovik.* Current Opinion in Chemical Biology, 2009, 13, 1-5.
- “Advances in Engineered Hemoproteins that Promote Biocatalysis.” Kari L. Stone and Syeda M. Ahmed. Inorganics 2016, 4(2), 12.
- "Manganese-Substituted Myoglobin: Characterization and Reactivity of an Oxidizing Intermediate towards a Weak C-H Bond.” Kari L. Stone*, Joey Hua, and Humdoon Choudhry. Inorganics 2015, 3, 219-229.
- “Preparation and Properties of an MnIV-Hydroxide Complex: Proton and Electron Transfer at a Mononuclear Manganese Site and its Relationship to the Oxygen Evolving Complex within Photosystem II.” Taketo Taguchi, Kari L. Stone, Rupal Gupta, Benedikt Kaiser-LaSalle, Junko Yano, Michael P. Hendrich, and A. S. Borovik.* Chemical Science, 2014, 5, 3064-3071
- “Formation, Structure, and EPR Detection of a High Spin FeIV-Oxo Species Derived from Either an FeIII-Oxo or FeIII-OH Complex.” David C. Lacy, Rupal Gupta, Kari L. Stone, John Greaves, Joseph W. Ziller, Michael P. Hendrich,* and A. S. Borovik.* Journal of the American Chemical Society, 2010, 132, 12188-12190 (Communication).
Peer-Reviewed and Invited Presentations:
- “Synthesis of 1st Row Transition Metal Complexes with Redox-active Ligands.” Science and Sociability Seminar, Benedictine University; February 5, 2010.
- "Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” Chicago ACS September 2012 Meeting, Benedictine University; September 20, 2012.
- “Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” 245th American Chemical Society Meeting. New Orleans, LA; April 2013.
- “Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” Faculty Colloquium, Benedictine University; April 19, 2013.
- “Preparation of Substituted Myoglobin to Promote New Reactivities.” 250th American Chemical Society Meeting. Boston, MA, 2015.
- “Preparation of Metal-replaced Myoglobin to Promote New Reactivities.” 246th American Chemical Society Meeting. Indianapolis, IN, 2013.
- “Synthesis of Transition Metal Complexes with Redox-active Ligands for Catalysis” Kari L. Stone. 243rd American Chemical Society. San Diego, CA, 2012.